Memory T-cells that have the 2C receptor interact with many MHC-I proteins.

2003 JUL 24 - (NewsRx.com & NewsRx.net) -- Memory T cells with the 2C receptor can interact with many classes of MHC-I proteins.

"When T-cell clones were first grown in long term cell culture, each clone was considered to be capable of displaying a limited range of functional activities, constrained by the clones' coreceptor, CD4 or CD8, and on the specificity of its antigen-specific receptor (TCR) for one or a few peptides in association with a class I or class II MHC molecule.

"Subsequent studies, especially with transgenic mice, have shown, however, that T cells expressing the same receptor can be obtained in a variety of differentiated states, including …